10-METHYLPHENOTHIAZINE
Base Information
- Chemical Name: 10-METHYLPHENOTHIAZINE
- CAS No.: 1207-72-3
10-METHYLPHENOTHIAZINE GMP Manufacturer Global Trade 1207-72-3 with Fast Delivery
- Molecular Formula: C13H11NS
- Molecular Weight: 213.303
- Appearance/Colour: Slightly yellow to pale green crystalline powder
- Vapor Pressure: 7.95E-05mmHg at 25°C
- Melting Point: 99-101 °C(lit.)
- Refractive Index: 1.665
- Boiling Point: 341.611 °C at 760 mmHg
- PKA: 0.56±0.20(Predicted)
- Flash Point: 160.401 °C
- PSA： 28.54000
- Density: 1.208 g/cm3
- LogP: 3.98410
10-METHYLPHENOTHIAZINE(Cas 1207-72-3) Usage
|
Purification Methods |
Recrystallise it (three times) from EtOH to give the -form (prisms). Recrystallisation from EtOH/*benzene gives the .-form (needles). It has also been purified by vacuum sublimation and is carefulmax 255nm (log 4.60) (pH 6.3) and 255nm in hexane. [Cymerman-Craig & Warburton Aust J Chem 9 294 1956, Beilstein 27 II 33, 27 III/IV 1215.] |
InChI:InChI=1/C13H11NS/c1-14-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,1H3
1207-72-3 Relevant articles
Design and synthesis of new theranostic agents for near-infrared imaging of β-amyloid plaques and inhibition of β-amyloid aggregation in Alzheimer's disease
Dao, Pascal,Ye, Feifei,Du, Zhi Yun,Chen, Qian,Zhang, Kun,Dong, Chang Zhi,Meunier, Bernard,Chen, Huixiong
, p. 130 - 140 (2017)
The presence of amyloid plaques predispo...
Alkyl length dependent reversible mechanofluorochromism of phenothiazine derivatives functionalized with formyl group
Jia, Junhui,Wu, Yuying
, p. 537 - 543 (2017)
A series of D-A typed phenothiazine deri...
Selective oxidaton methods for preparation of N-alkylphenothiazine sulfoxides and sulfones
Tosa, Monica,Paizs, Csaba,Majdik, Cornelia,Poppe, Laszlo,Kolonits, Pal,Silberg, Ioan A.,Novak, Lajos,Irimie, Florin-Dan
, p. 277 - 282 (2001)
Efficient and selective oxidation method...
Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies
Reddyrajula, Rajkumar,Dalimba, Udayakumar,Madan Kumar
, p. 263 - 282 (2019)
The objective of the current study is to...
Trans -A2B-corrole bearing 2,3-di(2-pyridyl)quinoxaline (DPQ)/phenothiazine moieties: Synthesis, characterization, electrochemistry and photophysics
Kandhadi, Jaipal,Yan, Wei-Cong,Cheng, Fan,Wang, Hui,Liu, Hai-Yang
, p. 9987 - 9999 (2018)
Two novel donor-acceptor systems (F10C-P...
Development of Phenothiazine-Based Theranostic Compounds That Act Both as Inhibitors of β-Amyloid Aggregation and as Imaging Probes for Amyloid Plaques in Alzheimer's Disease
Dao, Pascal,Ye, Feifei,Liu, Yan,Du, Zhi Yun,Zhang, Kun,Dong, Chang Zhi,Meunier, Bernard,Chen, Huixiong
, p. 798 - 806 (2017)
Early detection of Alzheimer's disease (...
A turn-on fluorescent BOPHY probe for Cu2+ ion detection
He, Chunhua,Zhou, Huipeng,Yang, Na,Niu, Niu,Hussain, Ejaz,Li, Yongxin,Yu, Cong
, p. 2520 - 2525 (2018)
A new fluorine-boron compound BOPHY-PTZ ...
Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups
Filip,Gl,Lupan,Perde-Schrepler,L?nnecke,Surducan,Gin,Hey-Hawkins,Silaghi-Dumitrescu
, p. 615 - 629 (2014)
The palladium and platinum complexes of ...
Photoinduced Electron Transfer from N-Alkylphenothiazines to Interface Water of Sodium Dodecyl Sulfate Micelles as a Function of Poly(ethylene oxide) Interaction with the Interface
Kang, Young Soo,Kevan, Larry
, p. 2478 - 2481 (1994)
Photoinduced electron transfer from N-al...
Benzothiazole-Phenothiazine Conjugate Based Molecular Probe for the Differential Detection of Glycated Albumin
Kumar, Ashish,Datta, Lakshmi Priya,Samanta, Sourav,Arora, Harshit,Govindaraju, Thimmaiah
, p. 222 - 230 (2021)
Glycation of albumin proteins is conside...
Phenothiazine-oxadiazole push-pull fluorophores: Combining high quantum efficiency, excellent electrochemical stability and facile functionalization
Wong, Michael Y.,Leung, Louis M.
, p. 542 - 549 (2017)
A series of five novel sky-blue to green...
-
Underberg
, p. 1128,1129 (1978)
-
Structure-reactivity relationship of probes based on the H2S-mediated reductive cleavage of the CC bond
Tan, Jingyun,Wang, Chunfei,Zhang, Xuanjun
, p. 11667 - 11677 (2020)
Recently, we discovered the H2S-mediated...
Charge Separation in Donor-Chromophore-Acceptor Assemblies: Linkage and Driving Force Dependence of Photoinduced Electron Transfers
Larson, S.L.,Elliott, C.Michael,Kelley, D.F.
, p. 6530 - 6539 (1995)
A series of covalently linked Ru(bipyrid...
Corrole-phenothiazine and porphyrin-phenothiazine dyads connected at β-position: Synthesis and photophysical properties
Kandhadi, Jaipal,Cheng, Fan,Wang, Hua-Hua,Ali, Atif,Wang, Li-Li,Wang, Hui,Liu, Hai-Yang
, p. 368 - 378 (2017)
Two novel donor-acceptor dyads, in which...
ELECTRON TRANSFER REACTIONS AT n-GaP (100) and (111) IN ACETONITRILE SOLUTIONS FACILITATED BY CATION ADSORPTION.
McIntyre,Gerischer
, p. 963 - 969 (1984)
Electron transfer reactions occurring at...
Cation radicals of N-substituted phenothiazines
Tomilin,Konovalova,Yuzhalkin,Ryabkina,Sanaeva
, p. 365 - 370 (1996)
The reaction of N-substituted phenothiaz...
-
Kan,Matsunaga
, p. 2096,2097 (1972)
-
MECHANISMS OF LIGHT-INITIATED REDOX REACTIONS OF COPPER(II)-CYCLIC POLYAMINE SURFACTANT ASSEMBLIES.
Moroi
, p. 3265 - 3270 (1981)
Photo-induced reduction of Cu**2** plus ...
Elucidating the Excited State of Mechanoluminescence in Organic Luminogens with Room-Temperature Phosphorescence
Yang, Jie,Gao, Xuming,Xie, Zongliang,Gong, Yanbin,Fang, Manman,Peng, Qian,Chi, Zhenguo,Li, Zhen
, p. 15299 - 15303 (2017)
Two stable, purely organic luminogens ex...
Bis(pentafluorophenyl)phenothiazylborane-an intramolecular frustrated Lewis pair catalyst for stannane dehydrocoupling
Bentley, Jordan N.,Caputo, Christopher B.,Pradhan, Ekadashi,Zeng, Tao
supporting information, p. 16054 - 16058 (2020/12/03)
We synthesized a novel Lewis acidic amin...
Synthesis, spectral characterization and antitumor activity of phenothiazine derivatives
Venkatesan, Kasi,Satyanarayana, Vardhineedi Sri Venkata,Sivakumar, Amaravadi,Ramamurthy, Chitteti,Thirunavukkarusu, Chinnasamy
, p. 2722 - 2728 (2020/04/16)
Different types of phenothiazine derivat...
1207-72-3 Process route
-
-
N-Methylphenothiazinium Perchlorate Cation Radical
-
-
536-74-3
phenylacetylene
-
-
75-05-8,26809-02-9
acetonitrile
-
-
1207-72-3
N-methylphenothiazine
-
-
2234-09-5
N-methylphenothiazine sulfoxide
-
-
605-02-7
1-phenylnaphthalene
-
-
53546-08-0
2-methyl-3,6-diphenyl pyridine
-
-
127665-98-9
C34 H28 N2 S2 (2+)
| Conditions | Yield |
|---|---|
|
at 0 ℃;
for 13h;
Product distribution;
Irradiation;
effect of irradiation;
|
-
-
92-84-2
10H-phenothiazine
-
-
74-88-4
methyl iodide
-
-
1207-72-3
N-methylphenothiazine
| Conditions | Yield |
|---|---|
|
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
|
99%
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 2h;
Cooling with ice;
|
97%
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 2h;
Cooling with ice;
|
97%
|
|
In
methanol;
at 90 ℃;
for 24h;
|
96.4%
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
|
96%
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
|
96%
|
|
1.) 120 deg C, 30 h, 2.) room temperature, 12 h;
|
94%
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Cooling with ice;
|
93.9%
|
|
With
sodium amide;
at 43 - 44 ℃;
for 12h;
|
91%
|
|
10H-phenothiazine; methyl iodide;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
With
hydrogenchloride;
In
water;
|
91.2%
|
|
10H-phenothiazine;
With
potassium tert-butylate;
In
tetrahydrofuran;
for 0.333333h;
Inert atmosphere;
Cooling with ice;
methyl iodide;
In
tetrahydrofuran;
Inert atmosphere;
|
90%
|
|
10H-phenothiazine;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
for 8h;
Inert atmosphere;
|
89%
|
|
10H-phenothiazine;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Cooling with ice;
methyl iodide;
In
tetrahydrofuran;
for 2h;
|
87%
|
|
10H-phenothiazine;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
methyl iodide;
In
tetrahydrofuran;
at 0 ℃;
for 12h;
|
82%
|
|
10H-phenothiazine;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.5h;
Sealed tube;
methyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
for 2h;
Sealed tube;
|
80%
|
|
In
methanol;
at 105 ℃;
for 18h;
|
79%
|
|
With
sodium hydride;
In
tetrahydrofuran;
|
76%
|
|
10H-phenothiazine;
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
65.5%
|
|
10H-phenothiazine;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.75h;
methyl iodide;
In
N,N-dimethyl-formamide;
at 40 ℃;
for 24h;
|
60%
|
|
|
|
|
Multistep reaction;
(i) Na, DMSO, (ii) /BRN= 969135/;
|
|
|
In
methanol;
|
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 2h;
Yield given;
|
|
|
With
sodium hydride;
In
dimethyl sulfoxide;
at 60 ℃;
for 1h;
|
|
|
With
sodium hydride;
Multistep reaction;
1.) THF, mineral oil, 2 h; 2.) THF, mineral oil, 2 h;
|
|
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 25 ℃;
for 1h;
|
|
|
10H-phenothiazine;
With
sodium hydride;
In
tetrahydrofuran;
Inert atmosphere;
Schlenk technique;
methyl iodide;
In
tetrahydrofuran;
Inert atmosphere;
Schlenk technique;
|
|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
for 12h;
Inert atmosphere;
|
|
|
10H-phenothiazine;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
for 0.5h;
Inert atmosphere;
|
|
|
With
sodium hydride;
|
|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
for 12h;
|
|
|
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 24h;
|
|
|
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 70 - 80 ℃;
for 24h;
|
1207-72-3 Upstream products
-
92-84-2
10H-phenothiazine
-
77-78-1
dimethyl sulfate
-
74-88-4
methyl iodide
-
98546-66-8
2-ethanesulfonylmethyl-5-bromo-thiophene
1207-72-3 Downstream products
-
19607-01-3
N(10)-methylphenothiazine-S,S-dioxide
-
6314-29-0
10-Methyl-phenthiazin-carbonsaeure-(1)
-
107624-59-9
10-methyl-10H -phenothiazine-1-carboxylic acid
-
109746-92-1
(10-methyl-10H -phenothiazin-4-yl)-phenyl-methanone
Product recommendations
- TRIACONTYLDIMETHYLCHLOROSILANE
- 3-HYDROXYPICOLINAMIDE
- 1-Ethylimidazolidine-2,4-dione
- 1-(4-cyanophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
- 3-methyl-5-[(6-sulpho-2-naphthyl)azo]salicylic acid
- 4'-chloro-2-(2,4-di-tert-pentylphenoxy)-3'-nitrobutyranilide
- 4-Methylbenzhydrol
- 3-[(4-amino-2,5-dimethylphenyl)azo]naphthalene-1,5-disulphonic acid