4-Chlorothiophenol

Base Information

  • Chemical Name: 4-Chlorothiophenol
  • CAS No.: 106-54-7

Top Quality Chinese Factory supply 106-54-7 4-Chlorothiophenol

  • Molecular Formula: C6H5ClS
  • Molecular Weight: 144.625
  • Appearance/Colour: white to almost white crystalline solid 
  • Vapor Pressure: 0.335mmHg at 25°C 
  • Melting Point: 49-51 °C 
  • Refractive Index: 1.5480 
  • Boiling Point: 206.8 °C at 760 mmHg 
  • PKA: pK1:5.9 (25°C) 
  • Flash Point: 78.6 °C 
  • PSA: 38.80000 
  • Density: 1.268 g/cm3 
  • LogP: 2.62870 

4-Chlorothiophenol(Cas 106-54-7) Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 4455, 1962 DOI: 10.1021/jo01059a081Synthetic Communications, 18, p. 575, 1988 DOI: 10.1080/00397918808064014

Hazard

Toxic by ingestion.

Purification Methods

Recrystallise the thiophenol from aqueous EtOH. The SMe ether has m 129o and the SEt ether has m 64o. [D'Sousa et al. J Org Chem 52 1720 1987, Beilstein 6 H 326, 6 I 149, 6 III 1034.]

General Description

4-Chlorothiophenol undergoes oxidative coupling catalyzed by iron(III)-tetra phenyl prophyrin to form disulfides.

InChI:InChI=1/C6H5ClS/c7-5-1-3-6(8)4-2-5/h1-4,8H/p-1

106-54-7 Relevant articles

-

Oae,Tsuchida

, p. 1283 (1972)

-

Specific features of reaction between 1,2-dinitro-and 1-nitro-2-thioethenes and hydrazine

Kretser,Kuz'mina,Lipina,Berkova,Berestovitskaya

, p. 1202 - 1203 (2003)

-

-

Fedor,Murty

, p. 8410,8411 (1973)

-

Oxidative Cyclization of 4-(2-Mercaptophenyl)-Substituted 4H-1,2,4-Triazolium Species to Tricyclic Benzothiazolium Salts

Ardón-Mu?oz, Luis G.,Bolliger, Jeanne L.

, (2022/04/12)

Herein we report a generally applicable ...

Novel synthesis method of chlorolucanthone

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Paragraph 0029; 0031; 0034; 0036; 0039; 0041; 0044; 0046, (2020/10/21)

The invention discloses a novel synthesi...

High-performance sono/nano-catalytic system: Fe3O4?Pd/CaCO3-DTT core/shell nanostructures, a suitable alternative for traditional reducing agents for antibodies

Taheri-Ledari, Reza,Maleki, Ali,Zolfaghari, Ehsan,Radmanesh, Maral,Rabbani, Hodjattallah,Salimi, Ali,Fazel, Ramin

, (2019/11/02)

Herein, a novel heterogeneous nanoscale ...

Novel synthesis method for thiophenol derivative

-

Paragraph 0018; 0035-0037, (2019/04/30)

The invention discloses a novel synthesi...

106-54-7 Process route

2,2'-dipyridyldisulphide
2127-03-9

2,2'-dipyridyldisulphide

4-chloro-benzenesulfonic acid
98-66-8

4-chloro-benzenesulfonic acid

triphenylphosphine
603-35-0

triphenylphosphine

2-Sulfanylpyridine
2637-34-5,73018-10-7

2-Sulfanylpyridine

p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

Conditions
Conditions Yield
In benzene; for 4h; Product distribution; Mechanism; Heating; further reaction partners - various diaryl disulfides;
53%
65%
S-(p-nitrophenyl) p-chlorothiobenzoate
24252-90-2

S-(p-nitrophenyl) p-chlorothiobenzoate

aniline
62-53-3

aniline

4-chlorobenzanilide
6833-15-4

4-chlorobenzanilide

4-nitrobenzoic acid methyl ester
619-50-1

4-nitrobenzoic acid methyl ester

4-nitrobenzanilide
3460-11-5

4-nitrobenzanilide

p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

Conditions
Conditions Yield
In methanol; at 55 ℃; for 72h; Rate constant; k2=60.2E-4 dm3mol-1S-1;

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