1-[2-(ethylthio)ethyl]-2-methyl-5-nitro-1H-imidazole
Base Information
- Chemical Name: 1-[2-(ethylthio)ethyl]-2-methyl-5-nitro-1H-imidazole
- CAS No.: 28795-33-7
Reputable manufacturer supply 1-[2-(ethylthio)ethyl]-2-methyl-5-nitro-1H-imidazole 28795-33-7 in stock with high standard
- Molecular Formula: C8H13 N3 O2 S
- Molecular Weight: 215.276
- Vapor Pressure: 3.04E-06mmHg at 25°C
- Boiling Point: 399.9°C at 760 mmHg
- PKA: 2.61±0.34(Predicted)
- Flash Point: 195.7°C
- PSA： 88.94000
- Density: 1.29g/cm3
- LogP: 2.37600
1-[2-(ethylthio)ethyl]-2-methyl-5-nitro-1H-imidazole(Cas 28795-33-7) Usage
InChI:InChI=1/C8H13N3O2S/c1-3-14-5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
28795-33-7 Relevant articles
Preparation method of high-purity tinidazole
-
Paragraph 0021-0022; 0024-0025; 0027-0028; 0030-0031, (2020/10/04)
The invention discloses a synthetic prep...
Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis
Li, Yiming,Rizvi, S. Aal-e-Ali,Hu, Deqing,Sun, Danwen,Gao, Anhui,Zhou, Yubo,Li, Jia,Jiang, Xuefeng
supporting information, p. 13499 - 13506 (2019/08/21)
Oxygenation is a fundamental transformat...
Regioselective Alkylation of 4(5)-Nitro-1H-Imidazoles in Acidic Media: Study of Temperature Effects
Rao, A. K. S. Bhujanga,Rao, C. Gundu,Singh, B. B.
, p. 2399 - 2402 (2007/10/02)
Alkylation of 4(5)-nitro-1H-imidazoles i...
28795-33-7 Process route
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110-77-0
2-(ethylsulfanyl)ethanol
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696-23-1,88054-22-2
2-methyl-5-nitro-1H-imidazole
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-
28795-33-7
1-(2-(ethylthio)ethyl)-2-methyl-5-nitro-1H-imidazole
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; acetic acid;
at 85 ℃;
|
51%
|
|
With
sulfuric acid; 4-methyl-2-pentanone;
at 90 - 95 ℃;
for 4h;
Large scale;
|
-
-
110-77-0
2-(ethylsulfanyl)ethanol
-
-
696-23-1,88054-22-2
2-methyl-5-nitro-1H-imidazole
-
-
13230-19-8
1-(2-ethylsulfanyl-ethyl)-2-methyl-4-nitro-1H -imidazole
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-
28795-33-7
1-(2-(ethylthio)ethyl)-2-methyl-5-nitro-1H-imidazole
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
acetic acid;
at 140 ℃;
for 5h;
Yields of byproduct given;
|
60%
|
|
With
sulfuric acid;
In
acetic acid;
at 80 ℃;
for 10h;
Yields of byproduct given;
|
45%
|
|
With
sulfuric acid;
In
acetic acid;
at 100 ℃;
for 10h;
Product distribution;
Mechanism;
study of temperature effects (70 - 140 deg C); regioselective alkylation;
|
28795-33-7 Upstream products
-
110-77-0
2-(ethylsulfanyl)ethanol
-
696-23-1
2-methyl-5-nitro-1H-imidazole
28795-33-7 Downstream products
-
13230-19-8
1-(2-ethylsulfanyl-ethyl)-2-methyl-4-nitro-1H -imidazole
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19387-91-8
tinidazole
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